Koneksa Insights
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Pre-PrintPublication
Driving Novel Endpoints and Study Designs In Amyotrophic Lateral Sclerosis
This pre-print examines ALSFRS-R subdomains in Amyotrophic Lateral Sclerosis (ALS) clinical studies, finding that fine and gross motor subdomains may be more sensitive to disease progression and presenting a novel non-linear method for defining fast and slow progressors.
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Study Design Considerations for Digital Assessments in Parkinson’s Disease Clinical Trials
Compare how in-clinic, burst, and weekly at-home assessment schedules change the sample size a Parkinson’s disease-modifying therapy trial needs to detect an effect.
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Compliance Analysis for Remote Spirometry in Mild to Moderate Asthma
See what 3,024 expected pulmonary function tests across three asthma studies reveal about whether patients reliably complete twice-daily spirometry at home.
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Cardiac Biomarkers in Fabry Disease
See how patients and clinicians shaped a composite cardiac biomarker concept for Fabry disease, combining wearables, ECG, diaries, and PROs into one measurement model.
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Poster Feature development of digital measures for the finger tapping task
Which finger tapping features actually track Parkinson’s symptoms? Koneksa tested six candidates against mPower study data to find out.
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Considerations for Conducting Bring Your Own “Device” (BYOD) Clinical Studies
Find out what sponsors need to plan for when designing Bring Your Own Device (BYOD) clinical studies, capturing more representative, free-living participant data without the biases of single-timepoint clinic visits.
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Recommendations for Defining and Reporting Adherence Measured by Biometric Monitoring Technologies: Systematic Review
Explore why inconsistent definitions of adherence across biometric monitoring technology studies make it harder to trust clinical trial data, and what standardized reporting could change.
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Clinical and Immunological Evaluation of Cat-Allergic Asthmatics Living With or Without a Cat
See why cat-allergic asthmatics who live with a cat needed significantly more medication, long-acting beta agonists, and high-potency corticosteroids, to achieve asthma control comparable to those without a cat at home.
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Closer to the Patient Means Better Decisions: Wearable Remote Monitoring of Patients with COVID-19 Lung Disease
Learn why wearable remote monitoring of pulmonary function, oxygen saturation, and exercise challenge tests could close a critical gap in understanding COVID-19’s long-term impact on lung function.
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Found 59 Results
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Article
Designing Evidence That Reflects Everyone: A Black History Month Perspective
Diversity in clinical trials is not only a social imperative, it is a scientific standard. February, during Black History Month, offers an important moment to reflect on both the historical... Download
Article
Measurement Strategy First: Designing Fit-for-Purpose Digital Endpoints
Clinical development has never had more tools at its disposal. Wearables, sensors, mobile apps, imaging, biomarkers, and real-world data streams are increasingly used to generate digital endpoints in clinical trials,... Download
Article
Celebrating Last Patient In for Koneksa’s Parkinson’s Disease Progression Study (KH007)
We are happy to announce that our clinical study KH007 (NCT06219629) of Disease Progression in Parkinson's Disease (PD) achieved the last patient in (LPI) on January 10, 2025. This is... Download
