Explore Koneksa’s digital biomarker preprints, including early research on digital measures, validation methods, and the use of digital biomarkers in clinical trials. These resources share emerging scientific work before peer review, helping advance discussion around digital measurement in clinical development.
This pre-print examines ALSFRS-R subdomains in Amyotrophic Lateral Sclerosis (ALS) clinical studies, finding that fine and gross motor subdomains may be more sensitive to disease progression and presenting a novel non-linear method for defining fast and slow progressors.
